Regional expression of L-type calcium channel subunits during cardiac development
نویسندگان
چکیده
منابع مشابه
Cardiac L-type calcium channel (Cav1.2) associates with subunits
The cardiac voltage-gated Ca channel, Cav1.2, mediates excitation-contraction coupling in the heart. The molecular composition of the channel includes the pore-forming 1 subunit and auxiliary 2/ -1 and subunits. Ca channel subunits, of which there are 8 isoforms, consist of 4 transmembrane domains with intracellular Nand C-terminal ends. The 1 subunit was initially detected in the skeletal musc...
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The molecular mechanisms underlying the developmental regulation of L-type voltage-dependent Ca(2+) channels (VDCCs) are still unknown. In this study, we have characterized the expression patterns of skeletal (alpha(1S)) and cardiac (alpha(1C)) L-type VDCCs during cardiogenic differentiation in H9C2 cells that derived from embryonic rat heart. We report that chronic treatment of H9C2 cells with...
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Steroid hormones control the expression of many cellular regulators, and a role for estrogen in cardiovascular function and disease has been well documented. To address whether the activity of the L-type Ca2+ channel, a critical element in cardiac excitability and contractility, is altered by estrogen and its nuclear receptor, we examined cardiac myocytes from male mice in which the estrogen re...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2004
ISSN: 1058-8388,1097-0177
DOI: 10.1002/dvdy.20023